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    ENDOTHELIN-1 AND ANGIOTENSIN II DRIVE KIDNEY INJURY

    Endothelin-1 and angiotensin II work in tandem to drive disease progression1-3

    ET-1 and Ang II play a key role in the mechanisms of disease in IgA nephropathy and FSGS.1-3

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    Elevated levels of endothelin-1 and angiotensin II result in:

    Mesangial proliferation and the inflammatory response
    Icon showing cross-section of Bowman's capsule, with emphasis on mesangial cell proliferation, inflammation, and proteinuria in IgA nephropathy
    in IgA nephropathy2,4,5
    Podocyte injury and loss
    Icon showing cross-section of Bowman's capsule, with emphasis on podocyte injury, matrix accumulation, and fibrosis in FSGS
    in FSGS2

    See the impact of proteinuria in IgA nephropathy

    Putting research into practice

    Ang II=angiotensin II; ET-1=endothelin-1; FSGS=focal segmental glomerulosclerosis; IgA=immunoglobulin A.

    References:

    1. Raina R, et al. Kidney Dis. 2020;6:22-34. 2. Komers R, et al. Am J Physiol Regul Integr Comp Physiol. 2016:R877-R884. 3. Kohan DE, et al. Kidney Int. 2014;86:896-904. 4. Dhaun N, et al. Br J Pharmacol. 2012;167:720-731. 5. Wyatt RJ, et al. New Engl J Med. 2013;368:2402-2414.

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