ENDOTHELIN-1 AND ANGIOTENSIN II DRIVE KIDNEY INJURY
Endothelin-1 and angiotensin II work in tandem to drive disease progression1-3
ET-1 and Ang II play a key role in the mechanisms of disease in FSGS.1-3
Elevated levels of endothelin-1 and angiotensin II result in:
Podocyte injury and loss
in FSGS2
See the impact of proteinuria in FSGS
Ang II=angiotensin II; ET-1=endothelin-1; FSGS=focal segmental glomerulosclerosis.
References:
1. Raina R, Chauvin A, Chakraborty R, et al. The role of endothelin and endothelin antagonists in chronic kidney disease. Kidney Dis (Basel). 2020;6(1):22-34. 2. Komers R, Plotkin H. Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease. Am J Physiol Regul Integr Comp Physiol. 2016;210(10):R877-R884. 3. Kohan DE, Barton M. Endothelin and endothelin antagonists in chronic kidney disease. Kidney Int. 2014;86(5):896-904. doi:10.1038/ki.2014.143